Glut2 in pancreas

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August undefined, 2024

WebJan 31, 2024 · Glucose transporter 2 (GLUT2), which is present within the plasma membrane of pancreatic β cells 8, plays an important role in glucose-induced insulin secretion from pancreatic β cells by ... WebAge-dependent Expression of GLUT2 in pancreas, liver, and intestine in KK and KKAy mice Dec 2012 - Present. The ultimate goal of our …

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WebNational Center for Biotechnology Information WebStreptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring alkylating antineoplastic agent that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. It is used in medicine for treating certain cancers of the islets of Langerhans and used in medical research to produce an animal model for hyperglycemia … bbc tigrinya news today

In pancreatic islets from type 2 diabetes patients, the dampened ...

WebOur Western blotting data show that the expression of Glut2 and Nkx6.1, the important pancreatic β-cell function markers, increased in the db/db group mice as compared to that in the non-diabetic groups, regardless of hydrolyzed SF treatment of the pancreatic tissue . WebMay 25, 2024 · To ascertain the function of GLUT2 in glucose uptake in human β cells, we used a GLUT2 inhibitor, fisetin 45, to block GLUT2 function in the hPSC-derived pancreatic β-like cells. We treated the β-like cells with increasing dosages of 0, 30, 60, 90 and 120 μM fisetin to determine the specificity of the GLUT2 inhibitor (Figs. S10a and S10b ). Web1.2.2.2 GLUT2. Glucose transporter 2 (GLUT-2) is a facilitative uniporter with a high transport capacity expressed in hepatocytes, pancreatic beta cells, and in intestinal and renal epithelial cells (Mueckler, 1994). GLUT2 is located on the basolateral membrane of enterocytes, mediating the efflux of glucose from enterocytes into the bloodstream. dazbee wasureji no kotonoha

Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and …

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WebJan 1, 1998 · In this study, we report that GLUT2 is a target molecule for MLD-STZ toxicity. Ex vivo, a gradual decrement of both GLUT2 protein and mRNA expression was found in pancreatic islets isolated from MLDSTZ-treated C57BL/6 male mice, whereas mRNA expression of β-actin, glucokinase, and proinsulin remained unaffected. WebJun 1, 2001 · Re-expression by transgenesis of GLUT1 or GLUT2 in pancreatic β-cells rescues the GLUT2-null mice from early death and normalizes both the first and second phases of glucose-induced insulin secretion, as assessed in vitro in islet perifusion experiments or in vivo during hyperglycemic clamps . The endocrine pancreas of these … dazbog 42WebJan 1, 2001 · Briefly, pancreatic β-cells express GLUT2 glucose transporters, which permit rapid glucose uptake regardless of the extracellular sugar concentration . At … dazbav

"WebOct 1, 2005 · These mechanisms suggest that apical GLUT2 is a potential therapeutic target for novel dietary or pharmacological approaches to control intestinal sugar delivery and thereby improve glycemic control. Diabetes management is directed toward control of postprandial fluctuations or excursions in blood glucose, which reflect the relative rates of ... " - Glut2 in pancreas

Glut2 in pancreas

The role of GLUT2 in dietary sugar handling - PubMed

WebJan 1, 2014 · Analyses of membrane sub-domain distribution of GLUT2 in primary isolated pancreatic β cells revealed that GLUT2 almost exclusively resides in non-lipid-raft microdomain in β-cell membrane (Ohtsubo et al. 2013).Furthermore, the disruption of the GLUT2-galectin lattice by genetic inactivation of GnT-IVa or by treatment of pancreatic … WebGLUT2-null mice are hyperglycemic, hypoinsulinemic, hyperglucagonemic, and glycosuric and die within the first 3 weeks of life. Their endocrine pancreas shows a loss of first phase glucose-stimulated insulin …

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WebEl GLUT2 es un transportador de glucosa con baja afinidad, se expresa en el hígado, riñón, células β del páncreas y en la membrana basolateral de las células epitelia- les del intestino delgado,7 El GLUT2 participa en la regulación de la secreción de insulina: sólo permite el transporte de glucosa cuando la concentración plasmática ... WebMay 25, 2024 · To ascertain the function of GLUT2 in glucose uptake in human β cells, we used a GLUT2 inhibitor, fisetin 45, to block GLUT2 function in the hPSC-derived pancreatic β-like cells.

WebAug 1, 2002 · Glut2 mRNA levels were analyzed in total RNA samples from whole pancreas. Because Glut2 expression is limited to β-cells, the dilution by exocrine cell mRNA did not affect the analysis. No significant differences were observed in Glut2 mRNA level or protein expression between control and Foxa2 loxP/loxP;Ins.Cre islets (Fig. 3A–C). WebFurthermore, some transporters (eg, GLUT4 and GLUT8) are regulated by their subcellular distribution. In addition to catalyzing glucose entry into cells, some isotypes (eg, GLUT2) seem to be involved in the mechanisms of glucosensing of pancreatic beta-cells, neuronal, or other cells, thereby playing a major role in the hormonal and neural control.

WebAug 13, 2024 · In Glut2 knockout mice in which expression of Glut2 in pancreatic β cells was rescued by expression of rat Glut1, food intake was smaller than in wildtype mice . Moreover, the effects of intracerebroventricular (i.c.v.) injection of d -glucose or 2DOG to decrease or increase food intake, respectively, were blunted in the knockout mice. WebJan 31, 2024 · Glucose transporter 2 (GLUT2), which is present within the plasma membrane of pancreatic β cells 8, plays an important role in glucose-induced insulin …

WebNov 25, 2014 · In pancreatic beta cells, GLUT2 is required for glucose-stimulated insulin secretion. In hepatocytes, suppression of GLUT2 expression revealed the existence of an unsuspected glucose output …

WebJun 26, 2024 · GLUT2: major glucose transporter required for glucose sensing and hepatic glucose output. Glucose transporter isoform 2 (GLUT2) represents the major member of the GLUT family in pancreatic beta cells and hepatocytes but is also abundant in intestine, kidney, and the central nervous system. dazbog k cupsWebApr 5, 2012 · Abstract and Figures. The glucose transporter GLUT4 is well known to facilitate the transport of blood glucose into insulin-sensitive muscle and adipose tissue. In this study, molecular ... bbc tonga eruptionWebMar 22, 2024 · Citation 12 Studies have shown that SREBP-1c in liver cells of diabetic rats can mediate the expression of GLUT2 gene stimulated by glucose. Citation 13, Citation 14 GLUT2 is mainly expressed in the basolateral membrane of the proximal tubules of the liver and pancreas and plays an important role in glucose homeostasis in the organism. dazbog power private limitedWebMay 1, 1993 · The gene encoding the predominant facilitative glucose transporter expressed in pancreatic β-cells and hepatocytes, termed GLUT2, has been cloned and … bbc torah ks2WebMay 12, 2024 · Early expression of PDX1 during embryogenesis correlates to the appearance of GLUT2 in pancreatic progenitor cells, underlining PDX1-controlled … dazbog castle rockWebMar 16, 2024 · Objective: Glucose transporter 2 (GLUT2) is expressed in the pancreatic β-cell, intestine, liver, and kidney in mice. Although GLUT2 is considered as a major regulator of insulin secretion, in vivo contribution of β-cell Glut2 to glucose-stimulated insulin secretion and systemic glucose homeostasis is undefined. Therefore, the main objective of this … dazbog god of sunWebJan 1, 2011 · GLUT2 is also expressed at a high level in the sinusoidal membrane of hepatocytes where the transporter may function both for glucose uptake and release from the cells. In pancreatic [3-cells, GLUT2 may be part of a glucose sensing system-linking variations in plasma glucose to insulin secretion (4). bbc timing set