Rbm47 isgylation
WebJul 5, 2024 · In addition, our functional analysis of RBM47 shows that the down-regulation of RBM47 during CRC progression may promote EMT and metastasis. Epithelial … WebRBM47 is a novel RBP conserved in vertebrates with three RRM domains whose contributions to various aspects of cellular functions are as yet emerging. Loss of RBM47 …
Rbm47 isgylation
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WebMay 29, 2024 · Rbm47 was found to promote IL-10 production in B cells. We found that Rbm47 promotes the stability of IL-10 mRNA by binding to AU-rich elements in the 3′ … WebAug 26, 2016 · ISGylation is known to inhibit the replication of many viruses, although pro-viral effects of ISGylation are also reported. Given that ISG15 and the enzymes involved in ISGylation are strongly induced upon virus infection, understanding the interplay between virus and ISGylation is an important issue in virus-host interaction.
WebFeb 1, 2024 · Rbm47 was found to promote IL-10 production in B cells. We found that Rbm47 promotes the stability of IL-10 mRNA by binding to AU-rich elements in the 3′ untranslated region of Il10 mRNA. In ... WebJun 23, 2024 · Immunoblot analysis of RBM47 and IFNAR1 in the lungs, livers, and spleens of RBM47 +/+ (WT) and RBM47 +/− mice. Each band represents tissue samples from one …
WebDec 10, 2024 · Knockdown of ISG15 in NB4 APL cells inhibited ISGylation and also attenuated ATRA-induced differentiation. In summary, we demonstrate the functional importance of UBE2L6 in ATRA-induced neutrophil differentiation of APL cells and propose that this may be mediated by its catalytic role in ISGylation. WebJan 15, 2024 · RBM47, HCK, CD53, TYROBP, and HAVCR2 were identified as common hub genes, which were validated to be upregulated in advanced atherosclerotic plaques, to …
WebAbstract. Background: ISGylation is the conjugation of ISG15 with target proteins.ISGylation occurs through an enzymatic cascade, which is similar to that of ubiquitination. Through ISGylation, ISG15 can bind to proteins involved in cell proliferation and differentiation, thus promoting genesis and progression of malignancies.
WebFeb 11, 2024 · ISGylation is believed to act by changing the steady-state levels of target viral proteins by proteasomal destruction, in a manner analogous to ubiquitin . Some cellular proteins, on the other hand, appear to be stabilized by ISGylation. One example is IRF3, thus enabling a prolonged antiviral response . cyndi nguyen councilwoman new orleans laWebMorphological and functional changes in cells during the epithelial-mesenchymal transition (EMT) process are known to be regulated by alternative splicing. However, only a few … cyndi myers integrative chiropracticWebFeb 1, 2024 · Interferon-stimulated gene 15 (ISG15) is a ubiquitin-like protein that conjugates to its target proteins to modify them through ISGylation, but the relevance of ISG15 … cyndi nguyen new orleansWebAug 29, 2013 · rbm47 Acts on Head Development Through the Wnt8a Signaling Pathway. To reveal the molecular mechanism of rbm47 in regulation of zebrafish head development, … cyndi phillips johnson facebookWebDec 10, 2024 · In addition to ISG15 and other elements of the cellular ISGylation machinery, UBE2L6 is induced by type 1 interferon signaling and contains an interferon-stimulated response element in its promoter region (Kim et al., 2004). ATRA has previously been shown to upregulate ISGylation machinery in NB4 cells and to stimulate ISGylation (Dao et al ... billy lewis lavinia tennWebThe interferon (IFN)-stimulated gene product 15 (ISG15) represents an ubiquitin-like protein (Ubl), which in a process termed ISGylation can be covalently linked to target substrates via a cascade of E1, E2, and E3 enzymes. Furthermore, ISG15 exerts functions in its free form both, as an intracellular and as a secreted protein. In agreement with its role as a type I … billy lewis poo finger lyricsWebantibody and the anti-RBM47 antibody, we demonstrated an inter-action between RBM47 and A1CF (Fig 2M). Collectively, these results show that RBM47 may be a component of the editosome complex. A B E C D Figure 1. RBM47 is a RNA-binding protein that is more abundant in the nucleus. A RBM47 protein characteristics. RRM, RNA recognition motif. billy lewis scream